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Shipping Weight:
3.00 LBS
Calculated at checkout

Support a decrease in insulin resistance in horses with equine metabolic syndrome (EMS) and/or pituitary pars intermedia dysfunction (PPID) aka Cushing’s disease.

Support a decrease in insulin resistance in horses with equine metabolic syndrome (EMS) and/or pituitary pars intermedia dysfunction (PPID) aka Cushing’s disease.

Why Choose InsulinWise?

InsulinWise is available only through a licensed veterinarian. Contact your vet for an ordering code today.

Equine metabolic syndrome (EMS) and pituitary pars intermedia dysfunction (PPID) have become more and more prevalent in our aging equine community. EMS is characterized by weight gain and insulin dysregulation that can lead to the development of laminitis. Horses that have developed PPID (Cushing’s disease) may also suffer from insulin resistance.

Decreasing insulin resistance and controlling weight through dietary supplementation in these individuals can provide a benefit by decreasing laminitis risk.


  • Maintains lower insulin levels, a marker of decreased insulin resistance
  • Reduces body weight
  • Supports increasing levels of adiponectin, an indictor of increased insulin sensitivity
  • Sustains a decreased risk of laminitis
  • Patent Pending

When health issues arise, always seek the advice of a licensed veterinarian who can help you choose the correct course of action for your horse. Supplements are intended to maintain healthy systems and support recovery and healing. They are not intended to treat or cure illness or injury.

Recommended for

Veterinarians frequently recommend InsulinWise to support the improvement of insulin sensitivity in horses suffering from insulin dysregulation. InsulinWise is recommended for:

• EMS horses that are suffering from insulin resistance
• Horses that have a past history of laminitis due to altered insulin regulation
• Horses that are overweight and at risk for developing equine metabolic syndrome (EMS)
• PPID (Cushing’s) horses that also exhibit insulin resistance



InsulinWise contains:

Active Ingredients

Lysine 1,605 mg
Leucine 1,150 mg
Resveratrol 750 mg
Quercetin 500 mg

This synergistic blend of polyphenols and amino acids, including leucine, support normal insulin regulation in horses showing symptoms of equine metabolic syndrome (EMS) or PPID horses exhibiting insulin resistance.

The propriety blend of ingredients in InsulinWise are research-proven to support lower insulin levels and increased adiponectin concentrations in horses suffering from insulin dysregulation. Maintaining normal levels of these hormones and decreasing insulin resistance can provide a clinical benefit by decreasing the risk of laminitis.

Research-proven to support decreased insulin resistance*

* Manfredi JM, Stapley ED, Nash D. Effects of a dietary supplement on insulin and adipokine concentrations in equine metabolic syndrome/insulin dysregulation. in Proceedings Am Assoc Equine Pract 2018; 64:473.

Phase one of the research: collection of new data                   

insulinwise-chart-0.jpg insulinwise-chart-1.jpg


Phase two of the research: review of historical data




InsulinWise serving instructions:

1 scoop = 28 grams

For all classes of horses and ponies, supplement at a rate of one scoop (28 grams) per day.

The amount provided can be split between a.m. and p.m. feedings by offering ½ scoop (14 grams) at each feeding.

For best results, mix into meal at time of feeding.

Exposure to air for extended periods of time will impact potency. Seal container tightly after each use. If mixing in with meals in advance of feeding, store in an airtight container.

Storage and Shelf life:

Store InsulinWise in a cool, dry place. Reseal lid during storage. Shelf life is 24 months from date of manufacture when stored under suitable conditions.

Available sizes :

2 lb (.910 kg) jar (contains 32 scoops)

5 lb (2.27 kg) bucket (contains 80 scoops)

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Kentucky Performance Products, LLC
P.O. Box 1013
Versailles, KY 40383
PH: 800-772-1988
PH: 859-873-2974
FAX: 859-873-1163